In animal replica scientific studies, codeine administered via the oral path to Expecting rats throughout the period of organogenesis enhanced resorptions and diminished fetal weights in a dose about 26 periods the utmost recommended human dose (MRHD) while in the existence of maternal toxicity (see Facts). For pregnant mice and rats that received promethazine at doses 0.05 to six situations the MRHD, during various periods of gestation, there have been conclusions of enhanced fetal resorptions and skeletal fragility, lowered pup pounds, and developmental delays of pups (see Details). Dependant on the animal facts, recommend pregnant women from the possible threat to some fetus.
This medication might contain sugar and/or Liquor. Caution is advised When you have diabetes, Alcoholic beverages dependence, or liver disorder. Talk to your health practitioner or pharmacist about applying this product safely and securely.
Keep in mind, retain this and all other medicines out in the attain of kids, under no circumstances share your medicines with Many others, and use this medication just for the indication prescribed.
Promethazine is contraindicated in comatose states, and in folks identified to be hypersensitive or to own experienced an idiosyncratic response to promethazine or to other
The concomitant use of Promethazine with Codeine Oral Option with all cytochrome P450 3A4 inducers or discontinuation of a cytochrome P450 3A4 inhibitor may possibly result in decreased codeine ranges, larger norcodeine ranges, and less metabolism by way of 2D6 with resultant lessen morphine levels.
Extensive-phrase use of opioid medication may perhaps have an affect on fertility (ability to have small children) in Adult males or Females. It isn't recognised no matter if opioid consequences on fertility are permanent.
Promethazine hydrochloride wasn't mutagenic from the in vitro bacterial reverse mutation assay or clastogenic from the in vitro Chinese hamster ovary (CHO) mobile chromosomal aberration assay.
This medication may perhaps cause you to far more delicate to your sun. Limit your time within the sun. Avoid tanning booths and sunlamps. Use sunscreen and put on protecting garments when outside. Tell your physician instantly if you have sunburned or have pores and skin blisters/redness.
If you employ opioid drugs while you're pregnant, your newborn could turn out to be dependent on the drug. This can result in everyday living-threatening withdrawal signs and symptoms in the infant soon after it is actually born. Toddlers born depending on opioids might require health care procedure for a number of weeks.
Lessen Seizure Threshold - Promethazine may possibly decreased seizure threshold. It should be utilised with warning in folks with seizure disorders or in persons who're utilizing concomitant prescription drugs, for instance narcotics get more info or neighborhood anesthetics, which can also have an affect on seizure threshold.
The following really serious adverse reactions are explained, or described in larger depth, in other sections:
A home teaspoon just isn't an correct measuring device and could lead on to overdosage. For prescriptions in which a measuring device is not really presented, a pharmacist can provide an acceptable measuring gadget and can offer Directions for measuring the right dose. Don't overfill. Rinse the measuring product with drinking water following each use.
Existence-threatening respiratory troubles (respiratory depression). PROMETHAZINE WITH CODEINE ORAL Remedy can cause breathing difficulties (respiratory depression) that can materialize at any time through remedy and can result in Demise. Your hazard of breathing troubles is greatest after you very first start getting PROMETHAZINE WITH CODEINE ORAL Remedy, are getting other medicines that might cause respiratory challenges, have sure lung issues, are aged or have specific other health issues.
When employed for an prolonged time, this medication may well not function likewise and could need diverse dosing. Communicate with your medical doctor if this medication stops Performing well.